Role of 5p15.33 (TERT-CLPTM1L), 6p21.33 and 15q25.1 (CHRNA5-CHRNA3) variation and lung cancer risk in never-smokers

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Role of 5p15.33 (TERT-CLPTM1L), 6p21.33 and 15q25.1 (CHRNA5-CHRNA3) variation and lung cancer risk in never-smokers.

Genome-wide association studies have provided evidence that common variation at 5p15.33 (TERT-CLPTM1L), 6p21.33 and 15q25.1 (CHRNA5-CHRNA3) influences lung cancer risk. To examine if variation at any of these loci influences the risk of lung cancer in never-smokers, we compared 5p15.33-TERT (rs2736100), 5p15.33-CLPTM1L (rs4975616), 6p21.33-BAT3 (rs3117582), 15q25.1-CHRNA3 (rs8042374) and 15q25....

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Chromosome 15q25 (CHRNA3-CHRNA5) Variation Impacts Indirectly on Lung Cancer Risk

Genetic variants at the 15q25 CHRNA5-CHRNA3 locus have been shown to influence lung cancer risk however there is controversy as to whether variants have a direct carcinogenic effect on lung cancer risk or impact indirectly through smoking behavior. We have performed a detailed analysis of the 15q25 risk variants rs12914385 and rs8042374 with smoking behavior and lung cancer risk in 4,343 lung c...

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Body mass index and lung cancer risk in never smokers

An elevated risk of lung cancer associated with lower levels of body mass index (BMI) has been reported in previous studies.1-9 However, the interpretation of the association between low BMI and lung cancer is complicated by the fact that weight loss may be a sign of smoking. In general, smokers tend to be lighter than non-smokers,1, 10-15 and it is believed that nicotine is responsible for the...

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Alcohol consumption and lung cancer risk in never smokers.

OBJECTIVE The main objective of this study is to analyse the role of alcohol consumption on lung cancer risk in people who have never smoked. METHODS We conducted a systematic review of the scientific literature following the PRISMA statement. We searched Medline, EMBASE and CINAHL using different combinations of MeSH terms and free text. We included cohort studies, pooled cohort studies and ...

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Lung cancer in never-smokers.

The therapeutic landscape of lung cancer has evolved tremendously over the past 10 years with the discovery of oncogenic drivers constitutively activated by mutation, translocation or fusion. An activating EGFR mutation or ALK rearrangement is present in around 15% of Caucasian patients with non-small cell lung cancer (NSCLC), with targeted therapy constituting the basis of upfront treatment fo...

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ژورنال

عنوان ژورنال: Carcinogenesis

سال: 2009

ISSN: 0143-3334,1460-2180

DOI: 10.1093/carcin/bgp287